Prince Seeiso of Lesotho was born 16 April 1966, the younger son of the late King Moshoeshoe II (1938–1996) and the late Queen 'Mamohato Bereng Seeiso (1941–2003). His brother is presently King Letsie III.
He married Princess Mabereng Seeiso of Lesotho. They have three children - Prince Bereng Constantine Seeiso, Princess Masentle Tabitha Seeiso and Prince Maupha David Seeiso.
Presently, he is Lesotho High Commissioner to the United Kingdom.
In 2006, along side Prince Harry of Wales, he created a charity called Sentebale to support organizations working with Lesotho's disadvantaged young people and children, particularly those orphaned as a result of HIV and AIDS.