Andrea Knecht de Massy was born 16 October 2008 in Monaco, the eldest of four daughters of Donatella Knecht de Massy and K. Sébastien Knecht de Massy. She is the paternal granddaughter of Christine-Alix de Massy and paternal great granddaughter of Princess Antoinette of Monaco, Barone de Massy. She has three older sisters:
She attends the private catholic school, L'Institut François d’Assise Nicolas Barré, along with her older sisters and second cousins once removed Princess Alexandra of Hanover and Camille Gottlieb. The youngest Knecht de Massy is presently in her second year at the nursey school division with her older sister Vittoria, while her other sisters and second cousins attend the upper division.